The role of diffusion-weighted imaging in the diagnosis of early kidney damage

Objective: This study aimed to determine a threshold value for distinguishing early-stage chronic kidney disease (CKD) from moderate and advanced stages as well patients with CKD those normal renal function using apparent diffusion coefficient (ADC) normalized ADC values. Methods: retrospective enrolled 257 patients. Diffusion-weighted images were obtained set of b = 50,400,800 In each patient, six values measured upper, middle, lower areas both kidneys, three the spleen. Patients classified into five subgroups healthy two according their glomerular filtration rate (GFR). Results: The found be positively correlated GFR (r 0.790, p < 0.001) negatively creatinine levels −0.709, 0.001). mean stage 1 2 groups significantly higher than advanced-stage (p 0.001), these in group With cut-off ≥1.791 ADC, sensitivity was 76.5% specificity 85% while between early- CKD. Conclusion: Renal are strongly stages, use appropriate values, difference early can predicted.